Perinatal inflammation, fetal growth restriction, and long-term neurodevelopmental impairment in Bangladesh.

ABSTRACT:

Background

There are limited data on the impact of perinatal inflammation on child neurodevelopment in low-middle income countries and among growth-restricted infants.

Methods

Population-based, prospective birth cohort study of 288 infants from July 2016-March 2017 in Sylhet, Bangladesh. Umbilical cord blood was analyzed for interleukin(IL)-1α, IL-1β, IL-6, IL-8, and C-reactive protein(CRP). Child neurodevelopment was assessed at 24 months with Bayley-III Scales of Infant Development. We determined associations between cord blood inflammation and neurodevelopmental outcomes, controlling for potential confounders.

Results

248/288 (86%) live born infants were followed until 24 months, among whom 8.9% were preterm and 45.0% small-for-gestational-age(SGA) at birth. Among

SUBMITTER: Lee AC 

PROVIDER: S-EPMC11959561 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature