TesG expression as a potential clinical biomarker for chronic Pseudomonas aeruginosa pulmonary biofilm infections.

ABSTRACT:

Background

Pseudomonas aeruginosa infections in the lungs affect millions of children and adults worldwide. To our knowledge, no clinically validated prognostic biomarkers for chronic pulmonary P. aeruginosa infections exist. Therefore, this study aims to identify potential prognostic markers for chronic P. aeruginosa biofilm lung infections.

Methods

Here, we screened the expression of 11 P. aeruginosa regulatory genes (tesG, algD, lasR, lasA, lasB, pelB, phzF, rhlA, rsmY, rsmZ, and sagS) to identify associations between clinical status and chronic biofilm infection.

Results

RNA was extracted from 210 sputum samples from patients (n = 70) with chronic P. aeruginosa lung infections (mean age; 29.3-56.2 years; 33 female). Strong biofilm formation was correlated with pro

SUBMITTER: Wannigama DL 

PROVIDER: S-EPMC11959726 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature