Cancer risk subsequent to cardiovascular disease: a prospective population-based study and meta-analysis.

ABSTRACT:

Background

Previous preclinical studies have revealed the biological links between cardiovascular diseases (CVD) and cancer. However, population-based evidence remained inconclusive.

Methods

We assessed cancer incidence among individuals with and without CVD condition in a prospective cohort from the UK Biobank (UKB). Multivariable Cox regression and competing risk models were fitted to estimate hazard ratios (HR). A systematic literature search was conducted in Medline, Embase and Cochrane Library databases to identify published population-based cohort studies (last updated on 1 October 2023) investigating the associations between CVD status and subsequent cancer risk. Random-effects meta-analysis was employed to pool relative effect estimates reported by eligible cohorts.

SUBMITTER: Shu C 

PROVIDER: S-EPMC11959738 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature