Downregulation of FASN in granulosa cells and its impact on ovulatory dysfunction in PCOS.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a complicated endocrinological and anovulatory disorder in women. Mice exposed to dihydrotestosterone (DHT) exhibit a PCOS-like phenotype characterized by abnormal steroid hormone production and ovulation dysfunction. The present investigation aims to identify overlapping genes expressed in PCOS patients and a PCOS mouse model induced by DHT and to examine the function of key genes fatty acid synthase (FASN) in hormone production and ovulation dysfunction.

Results

We examined 5 datasets of high-throughput mRNA transcription from the Gene Expression Omnibus (GEO) database, including 4 datasets from individuals with PCOS and 1 dataset from a DHT-induced mouse model. GO and KEGG enrichment analyses revealed these differentially exp

SUBMITTER: Tan Z 

PROVIDER: S-EPMC11959749 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature