Association between oral microbiome and sleep disorders in U.S. adults: analysis of NHANES database 2009-2012.

ABSTRACT:

Background

The microbiome, especially the gut microbiome, contributes to the regulation, etiology, and pathogenesis of sleep disorder. However, limited evidence regarding the oral microbiome's role in sleep disorder. Therefore, this study aimed to investigate the association between sleep disorder and oral microbial diversity and whether oral microbiota is associated with all-cause mortality in people with sleep disorder.

Methods

The study included 4,729 individuals in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2012 and mortality data until 2019. Sleep disorder was assessed by structured questionnaire. The oral microbiome was characterized by 16 S ribosomal RNA gene sequencing. Logistic regression models were conducted to quantify the associat

SUBMITTER: Hao G 

PROVIDER: S-EPMC11959752 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature