Evaluation of QuantiFERON TB gold plus among TB household contacts in high incidence settings.

ABSTRACT:

Background

Accurately identifying and categorizing individuals who are latently infected is critical for developing prevention strategies against tuberculosis (TB) disease. The QuantiFERON-TB Gold Plus (QFT-Plus), a set of two antigen tubes, was used to assess TB household contacts, aiming to induce CD4 + and CD8 + T cell responses.

Methods

We examined fifty-six TB household contacts for TB infection using the QFT-Plus and QFT-Gold In-Tube (QFT-GIT) tests. In addition, we evaluated 616 samples from the parent study to determine whether there was any association between the QFT-Plus CD8 + T cell responses and variables that were clinically significant. This was done by analyzing the difference in interferon-gamma (IFNγ) levels between TB2 and TB1 tubes. We utilised a cut-off

SUBMITTER: Nalukwago S 

PROVIDER: S-EPMC11959818 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature