Red blood cell transfusion strategy in traumatic brain injury patients: a systematic review and meta-analysis.

ABSTRACT:

Background

The optimal red blood cell transfusion (RBCT) strategy for traumatic brain injury (TBI) patients remains a topic of debate. This systematic review and meta-analysis aimed to compare the outcomes of a liberal transfusion strategy versus a restrictive strategy in critically ill patients with TBI.

Methods

PubMed, Web of Science, Embase, and Cochrane Library were searched from inception to November 17, 2024. We included randomized controlled trials (RCTs) of critically ill adult patients with TBI, reporting data on RBCT strategies. The outcomes included intensive care unit (ICU) mortality, long-term mortality, unfavorable functional outcomes, and the incidence of adverse events, such as transfused acute respiratory distress syndrome (TARDS) and venous thromboembolism.

SUBMITTER: Wang J 

PROVIDER: S-EPMC11959887 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature