Deciphering the integrated immunogenomic landscape of colorectal cancer: insights from Mendelian randomization and immune-stratified molecular subtyping.

ABSTRACT:

Purpose

This study aimed to decipher the intricate interplay between the immune landscape and CRC pathogenesis, elucidating how distinct immunophenotypes causally influence disease susceptibility and stratify patient outcomes.

Methods

We obtained the immunocyte phenotypes and CRC data from their respective genome-wide association studies. The primary analysis used the inverse variance weighting (IVW) method. We also simultaneously employed MR-Egger, weighted mode, simple mode, and weighted median approaches to strengthen the findings. Consensus clustering stratified 619 TCGA CRC patients by immunome expression. Functional assays examined the tumor suppressor GPD1L.

Results

The IVW MR analysis identified 17 immunocyte phenotypes positively potentially associated with i

SUBMITTER: He KJ 

PROVIDER: S-EPMC11959972 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature