GrcC1 mediates low-level resistance to multiple drugs in <i>M. marinum</i>, <i>M. abscessus,</i> and <i>M. smegmatis</i>.

ABSTRACT: The escalating threat of mycobacterial infectious diseases, particularly those caused by nontuberculous mycobacteria (NTM), poses a serious challenge to public health. Linezolid (LZD), an oxazolidinone antimicrobial, exhibits potent activity against Mycobacterium tuberculosis and NTM. Generally, mutations in the rrl and rplC genes are widely associated with resistance to LZD. However, in this study, we screened Mycobacterium marinum strains lacking such mutations, indicating the presence of an alternative resistance mechanism. Notably, through whole-genome sequencing, we identified a novel mutation C395T in the MMAR_0911 (grcC1) gene that has never been linked to drug resistance. This mutation leads to an A132V substitution in the encoded protein,

SUBMITTER: Fang C 

PROVIDER: S-EPMC11960048 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature