The host susceptibility/resistance-related genes and gut microbial characteristics in <i>Salmonella pullorum</i>-infected chickens.

ABSTRACT: Pullorum disease is a bacterial disease caused by Salmonella pullorum in chickens, which is characterized by gastrointestinal infection and diarrhea. In traditional perspectives, research on pullorum disease primarily focused on clinical symptoms, epidemiological characteristics, and the pathogenic sites. This study, however, approaches the subject from the standpoint of host genetic basis and gut microbiota. For the positive and negative offspring chicks, which are the offspring of positive roosters and hens and negative roosters and hens, respectively, we conducted whole-genome association analysis and identified 195 SNPs and 79 significant InDels on the host genome that were associated with susceptibility/resistance to pullorum disease. A total of 77 genes were annotated, among w

SUBMITTER: Ding J 

PROVIDER: S-EPMC11960056 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature