Outer membrane permeability of <i>Pseudomonas aeruginosa</i> through β-lactams: new evidence on the role of OprD and OpdP porins in antibiotic resistance.

ABSTRACT: Gram-negative bacteria are a major concern for public health, particularly due to the continuous rise of antibiotic resistance. A major factor that helps the development of resistance is the outer membrane that is essential since it acts as a strong permeability barrier to many antibiotics that are effective against other bacteria. In this study, we determine the specific permeability coefficients for various antibiotics in Pseudomonas aeruginosa strains, which differ from each other for their porin expressions. We showed that OprD and OpdP porins contribute both to internalize meropenem and biapenem. Using qRT-PCR, we demonstrated that their expression is dependent of the various phases of cellular growth. We were able to show how the OpdP porin is less expressed in exponential gro

SUBMITTER: Amisano F 

PROVIDER: S-EPMC11960084 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature