Brainwide mesoscale functional networks revealed by focal infrared neural stimulation of the amygdala.

ABSTRACT: The primate amygdala serves to evaluate the emotional content of sensory inputs and modulate emotional and social behaviors; it modulates cognitive, multisensory and autonomic circuits predominantly via the basal, lateral and central nuclei, respectively. Recent evidence has suggested the mesoscale (millimeter-scale) nature of intra-amygdala functional organization. However, the connectivity patterns by which these mesoscale regions interact with brainwide networks remain unclear. Using infrared neural stimulation of single mesoscale sites coupled with mapping in ultrahigh field 7-T functional magnetic resonance imaging, we have discovered that these mesoscale sites exert influence over a surprisingly extensive scope of the brain. Our findings strongly indicate that mesoscale sites within

SUBMITTER: Ping A 

PROVIDER: S-EPMC11960096 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature