The rise in domestic shigellosis and the genomic characteristics of <i>Shigella</i> clones linked to men who have sex with men in Taiwan, 2015‒2022.

ABSTRACT: Since 2015, Taiwan has experienced a notable rise in domestic shigellosis cases, particularly among young adult males. In this study, we aimed to investigate this epidemiological trend through demographic analysis and genomic characterization of bacterial isolates. We analyzed demographic data on shigellosis cases from 2003-2014 to 2015-2022. For cases from 2015-2022, we conducted genomic analyses of Shigella isolates using pulsed-field gel electrophoresis (PFGE) and whole-genome sequencing (WGS). Antimicrobial resistance and plasmid profiles were examined to identify genetic determinants of resistance. From 2015 to 2022, there was a noticeable demographic shift in domestic shigellosis cases from females to males and children to young adults. This trend was driven by three multidrug

SUBMITTER: Liao Y-S 

PROVIDER: S-EPMC11960102 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature