Evaluation of hepatitis A virus recombinant proteins for detecting anti-HAV IgM and IgG antibodies.

ABSTRACT: Hepatitis A virus (HAV) is a major causative agent of self-limiting liver infections. India was highly endemic for HAV in the past; children were exposed to the virus at an early age without any disease symptoms and developed lifelong immunity. With improvements in living conditions, an epidemiological transition is occurring. There is a significant increase in hepatitis A outbreaks involving adolescents and young adults. The gold standard for hepatitis A diagnosis is anti-HAV IgM antibodies. Although antibody responses are primarily targeted against HAV structural proteins (capsid proteins), non-structural proteins are also immunogenic. In the present study, we expressed HAV capsid proteins VP1-2A, VP0 (VP4 + VP2), VP3, and non-structural protein 3C^Pro in the bacterial system a

SUBMITTER: Hunderkar S 

PROVIDER: S-EPMC11960113 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature