A novel transcriptional regulator, CdeR, modulates the type III secretion system via c-di-GMP signaling in <i>Dickeya dadantii</i>.

ABSTRACT: Dickeya dadantii is a bacterial pathogen that causes soft rot disease in many plant species worldwide, including temperate, subtropical, and tropical regions. This bacterium employs the type III secretion system (T3SS) to manipulate host immune responses. Although cyclic-di-GMP (c-di-GMP), a ubiquitous bacterial second messenger, negatively regulates the expression of T3SS genes in D. dadantii, the underlying mechanism remains unclear. In this study, we identified a potential transcriptional regulator, CdeR, which regulates the T3SS involving c-di-GMP. Through transposon mutagenesis, we discovered that deletion of cdeR in a gcpD mutant background restored T3SS gene expression. GcpD is a diguanylate cyclase responsible for c-di-GMP synthesis, and its deletion led

SUBMITTER: Ghasemi A 

PROVIDER: S-EPMC11960120 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature