Comparative real-world outcomes of stage III melanoma patients treated with talimogene laherparepvec or interleukin 2.

ABSTRACT:

Background

Talimogene laherparepvec (T-VEC) and interleukin-2 (IL-2) are both used in the intralesional treatment of melanoma skin metastases. T-VEC received regulatory approval from the European Medicines Agency and the U.S. Food and Drug Administration in 2015, while IL-2 has been used off-label for this purpose for many years. Despite their use in clinical practice, there is a lack of comparative data on the efficacy and safety of these treatments.

Objectives

This retrospective study aimed to compare the efficacy and safety of intralesional T-VEC and IL-2 in non-resectable stage III patients with melanoma treated at a single center between January 2016 and September 2024.

Methods

We identified eligible patients using the Central Malignant Melanoma Registry and the

SUBMITTER: Reitmajer M 

PROVIDER: S-EPMC11960150 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature