Autophagy-related genes in mesial temporal lobe epilepsy: an integrated bioinformatics analysis.

ABSTRACT:

Background

Autophagy plays essential roles in the development and pathogenesis of mesial temporal lobe epilepsy (mTLE). In this research, we aim to identify and validate the autophagy-related genes associated with mTLE through bioinformatics analysis and experimental validations.

Methods

We obtained the dataset GSE143272 and high-throughput sequencing results of mTLE from public databases. Potential differentially expressed autophagy-related genes related to mTLE were identified using R software. Subsequently, genomes pathway enrichment analysis, protein-protein interactions (PPIs), and the gene ontology (GO) enrichment were performed for the selected autophagy-related genes. The mRNA expression profiles of hub genes were then used to establish a least absolute shrinkage and

SUBMITTER: Yang M 

PROVIDER: S-EPMC11960276 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature