Interaction between the <i>TCF7L2</i> gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults.

ABSTRACT:

Introduction

Transcription factor-7-like 2 (TCF7L2) is the most critical type 2 diabetes (T2D) gene identified to date. The single-nucleotide polymorphism (SNP) rs7903146 in TCF7L2 in T2D interacts with dietary factors; however, research on nutrigenetics among Saudi Arabians is limited. This study investigated the interaction between the SNP rs7903146 and dietary intake on factors that may contribute to MetS among Saudi Arabian adults.

Methods

This cross-sectional study included 271 adult participants (aged 20-55 years) of both genders with or without overweight or obesity (body mass index between 18-35 kg/m²). Anthropometric measurements and dietary assessments using a food frequency questionnaire were performed. Fasting blood samples were collected

SUBMITTER: Al-Odinan MS 

PROVIDER: S-EPMC11960299 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature