The associations between oxidative stress and epilepsy: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Studies on the association between oxidative stress and epilepsy have yielded varied results. In this study, we aimed to investigate the causal relationship between oxidative stress markers and epilepsy.

Methods

A bidirectional two-sample Mendelian randomization (MR) study was performed based on publicly available statistics from genome-wide association studies. To explore the causal effects, single nucleotide polymorphisms were selected as instrumental variables. Inverse-variance weighted method was performed for primary analysis, supplemented by weighted median, MR-Egger, simple mode, and weighted mode. Furthermore, sensitivity analyses were performed to detect heterogeneity and pleiotropy.

Results

Our results showed that part of the oxidative stress biom

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11960306 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature