Molecular epidemiology and β-lactam resistance mechanisms of <i>Enterobacter cloacae</i> complex isolates obtained from bloodstream infections, Kyoto, Japan.

ABSTRACT: The Enterobacter cloacae complex (ECC) comprises multiple species that require genomic analysis for precise identification. They produce inducible AmpC β-lactamase and may carry acquired β-lactamases, which are responsible for cefotaxime and cefepime resistance. To determine the molecular epidemiology, antimicrobial resistance, and β-lactam resistance mechanisms of the ECC, we conducted whole-genome sequencing analysis, antimicrobial susceptibility testing, and mutation analysis on bloodstream ECC isolates from patients in Kyoto, Japan. In 194 ECC isolates, 13 species and six unnamed taxa were identified, with Enterobacter xiangfangensis (36%) being the most common. A total of 38% of the isolates were nonsusceptible to cefotaxime and presented relatively high nonsusceptibilit

SUBMITTER: Matsuo A 

PROVIDER: S-EPMC11960451 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature