The N-terminus of the <i>Chlamydia trachomatis</i> effector Tarp engages the host Hippo pathway.

ABSTRACT: Chlamydia trachomatis (Ct) is an obligate, intracellular Gram-negative bacteria and the leading bacterial sexually transmitted infection in the United States. Chlamydia manipulates the host cell biology using various secreted bacterial effectors during its intracellular development. The early effector translocated actin-recruiting phosphoprotein (Tarp), important for Chlamydia entry, has a well-characterized C-terminal region which can polymerize and bundle F-actin. In contrast, not much is known about the function of the N-terminus of Tarp (N-Tarp), though present in many Chlamydia spp. To address this, we use Drosophila melanogaster as an in vivo cell biology platform to study N-Tarp-host interactions. Transgeni

SUBMITTER: Aranjuez GF 

PROVIDER: S-EPMC11960468 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature