Hydrogen Sulfide Sustained Release Donor Alleviates Spinal Cord Ischemia-Reperfusion-Induced Neuron Death by Inhibiting Ferritinophagy-Mediated Ferroptosis.

ABSTRACT:

Aims

Spinal cord ischemia-reperfusion injury (SCIRI) is a disastrous complication that cannot be completely prevented in thoracoabdominal aneurysm surgery, leading to sensory and motor dysfunction and even paraparesis, causing tremendous socioeconomic burden. Ferritinophagy is a form of autophagic ferroptosis, which is a contributor to SCIRI. Hydrogen sulfide (H₂S) has been reported to be neuroprotective in various diseases. However, it remains unclear whether H₂S alleviates SCIRI-induced neural death via regulating ferritinophagy-mediated ferroptosis. The aim of this study was to explore their relationship and interaction in SCIRI.

Results

The results demonstrate that Nissl bodies and motor function were obviously lost in SCIRI rats. Meanwhile, SCIRI l

SUBMITTER: Xie L 

PROVIDER: S-EPMC11960479 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature