SHMT2 is essential for mammalian preimplantation embryonic development through <i>de novo</i> biosynthesis of nucleotide metabolites.

ABSTRACT: Assisted reproductive technology (ART) is used widely and efficiently to treat infertility. During the ART procedure, one of the main factors affecting the success rate is abnormal development of preimplantation embryos. The establishment and maintenance of developmental competence are precisely regulated at different levels, while minor errors at early stages may result in adverse outcomes, including developmental arrest and implantation failure. As one of the major inputs, the regulatory mechanisms of metabolites in embryonic development are less known. In this study, we investigated the functional relevance of the metabolic enzyme serine hydroxymethyltransferase 2 (SHMT2) and deoxyribonucleotide (dNTP) metabolites in mouse preimplantation embryonic development. By using a well-character

SUBMITTER: Shi M 

PROVIDER: S-EPMC11960634 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature