Transcriptomic and proteomic effects of gene deletion are not evolutionarily conserved.

ABSTRACT: Although the textbook definition of gene function is the effect for which the gene was selected and/or by which it is maintained, gene function is commonly inferred from the phenotypic effects of deleting the gene. Because some of the deletion effects are byproducts of other effects, they may not reflect the gene's selected-effect function. To evaluate the degree to which the phenotypic effects of gene deletion inform gene function, we compare the transcriptomic and proteomic effects of systematic gene deletions in budding yeast (Saccharomyces cerevisiae) with those effects in fission yeast (Schizosaccharomyces pombe). Despite evidence for functional conservation of orthologous genes, their deletions result in no more sharing of transcriptomic or proteomic effects than that f

SUBMITTER: Li Y 

PROVIDER: S-EPMC11960704 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature