Radiofrequency or cryoablation or medical therapy for paroxysmal atrial fibrillation: An indirect comparison of effectiveness.

ABSTRACT:

Background

Paroxysmal atrial fibrillation (PAF) is commonly treated with pharmacological therapies, but these may be insufficient for symptom control. Radiofrequency and cryoballoon ablation have emerged as alternative strategies. This study aimed to compare the efficacy of cryoballoon ablation, radiofrequency ablation, and anti-arrhythmic drugs as initial therapies for symptomatic PAF based on randomized trial data.

Methods

Data were extracted from randomized trials, and individual patient data were reconstructed from Kaplan-Meier curves using artificial intelligence techniques. Time-to-event analysis was performed to evaluate arrhythmia recurrence, with hazard ratios (HRs) as the primary measure of efficacy. A heterogeneity analysis was conducted to assess variability betw

SUBMITTER: Brunoro R 

PROVIDER: S-EPMC11960708 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature