Optical characteristics of human lung cancer for photodynamic therapy with measured absorption and reduced scattering coefficients.

ABSTRACT:

Significance

The optical characteristics of a human lung, such as the light distribution in the tissue, are crucial for evaluating the light delivery of photodynamic therapy (PDT) for peripheral lung cancer.

Aim

The light distribution in the human lung is analyzed with absorption ( μa ) and reduced scattering ( μs' ) coefficients measured ex vivo for normal, carbon-deposited, and tumor tissues.

Approach

The μa and μs' spectra were measured using a double-integrating-sphere optical system and inverse Monte Carlo technique. The measured values were used to perform a light distribution analysis using a Monte Carlo light transport simulation.

Results

The μa values varied between tissue types owing to the influence of carbon deposition, blood volume fraction,

SUBMITTER: Shimojo Y 

PROVIDER: S-EPMC11960791 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature