Lifetime history of gestational diabetes and cognitive function in parous women in midlife.

ABSTRACT:

Aims/hypothesis

We aimed to determine whether a history of gestational diabetes mellitus (GDM) is associated with cognitive function in midlife.

Methods

We conducted a secondary data analysis of the prospective Nurses' Health Study II. From 1989 to 2001, and then in 2009, participants reported their history of GDM. A subset participated in a cognition sub-study in 2014-2019 (wave 1) or 2018-2022 (wave 2). We included 15,906 parous participants (≥1 birth at ≥18 years) who completed a cognitive assessment and were free of CVD, cancer and diabetes before their first birth. The primary exposure was a history of GDM. Additionally, we studied exposure to GDM and subsequent type 2 diabetes mellitus (neither GDM nor type 2 diabetes, GDM only, type 2 diabetes only or GDM followed by

SUBMITTER: Soria-Contreras DC 

PROVIDER: S-EPMC11960863 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature