Change in D3Cr muscle mass in oldest old men and its association with changes in grip strength and walking speed.

ABSTRACT:

Background

The use of lean soft tissue (LST) mass as a surrogate measurement of skeletal muscle mass (SMM) has led to the conclusion that muscle loss is poorly related to functional decline. We hypothesized that when using a more accurate measure of SMM determined by D3-creatine dilution (D3Cr), longitudinal changes in SMM will be similar in magnitude to changes in strength and physical performance and that skeletal muscle mass will partially mediate the relationship of age with these outcomes.

Methods

We measured change in D3Cr muscle mass (kg), handgrip strength (kg), and 6m walk speed (m/s) in 208 men from the Osteoporotic Fractures in Men Study (85.2 ± 4.3 years) over an average of 6.1 years follow-up. Mixed linear effects models adjusted for potential confounders were u

SUBMITTER: Hetherington-Rauth M 

PROVIDER: S-EPMC11960989 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature