GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans.

ABSTRACT: Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to patients with obesity and observed a heightened sense of preingestive satiation. Analysis of human and mouse brain samples pinpointed GLP-1 receptor (GLP-1R) neurons in the dorsomedial hypothalamus (DMH) as candidates for encoding preingestive satiation. Optogenetic manipulation of DMH^GLP-1R neurons caused satiation. Calcium imaging demonstrated that these neurons are actively involved in encoding preingestive satiation. GLP-1RA administration increased the activity of DMH^GLP-1R neurons selectively during eating behavior. We further identified that an intricate interplay between DM

SUBMITTER: Kim KS 

PROVIDER: S-EPMC11961025 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature