Heterochromatin protein 1 (HP1) of Schistosoma mansoni: non-canonical chromatin landscape and oviposition effects.

ABSTRACT:

Background

Heterochromatin protein 1 (HP1) is widespread in several organisms playing a role in control of gene expression by heterochromatin formation and maintenance of silent chromatin. Schistosoma mansoni is a human parasite that is responsible for Schistosomiasis, a tropical neglected disease in the tropical and subtropical areas in the world, where the intermediate host Biomphalaria glabrata is present.

Objectives

In this study we attempted to investigate if the SmHP1 is enriched in S. mansoni chromatin in cercariae larvae stage, compared with another larvae stage sporocysts and its importance for S. mansoni life cycle progression and parasite oviposition.

Methods

We used ChIPmentation with commercial antibody ab109028 that passed in-house quality control. We al

SUBMITTER: da Trindade NS 

PROVIDER: S-EPMC11961034 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature