Increased nuchal translucency thickness and normal chromosomal microarray: Danish nationwide cohort study.

ABSTRACT:

Objective

To assess the outcome of pregnancies with increased fetal nuchal translucency (NT) thickness and a normal result from chromosomal microarray (CMA) vs conventional karyotyping.

Methods

This was a Danish nationwide registry-based cohort study of all singleton pregnancies seen for combined first-trimester screening between 2008 and 2018. Data on NT thickness and pregnancy outcome were retrieved from the Danish Fetal Medicine Database, whereas data on cytogenetic and molecular karyotypes were retrieved from the Danish Cytogenetic Central Register. Pregnancies were stratified according to NT thickness, and we computed the prevalence of chromosomal aberration, termination of pregnancy (due to non-genetic abnormal findings aside from increased NT), pregnancy loss, major c

SUBMITTER: Gadsboll K 

PROVIDER: S-EPMC11961099 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature