An <i>in Vivo</i> Nanosensor Measures Compartmental Doxorubicin Exposure.

ABSTRACT: Preclinical measurements of drug exposure to specific organs and tissues is normally performed by destructive methods. Tissue-specific measurements are important, especially for drugs with intractable dose-limiting toxicities, such as doxorubicin-mediated cardiotoxicity. We developed a method to rapidly quantify doxorubicin exposure to tissues within living organisms using an implantable optical nanosensor that can be interrogated noninvasively following surgical implantation. The near-infrared fluorescence of single-walled carbon nanotubes functionalized with DNA was found to respond to doxorubicin via a large and uniform red-shift. We found this to be common to DNA-intercalating agents, including anthracycline compounds such as doxorubicin. Doxorubicin was measured in buffer and serum, i

SUBMITTER: Harvey JD 

PROVIDER: S-EPMC11961114 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature