Biodiversity-based identification and functional characterization of the mannose-specific adhesin of Lactobacillus plantarum.

ABSTRACT: Lactobacillus plantarum is a frequently encountered inhabitant of the human intestinal tract, and some strains are marketed as probiotics. Their ability to adhere to mannose residues is a potentially interesting characteristic with regard to proposed probiotic features such as colonization of the intestinal surface and competitive exclusion of pathogens. In this study, the variable capacity of 14 L. plantarum strains to agglutinate Saccharomyces cerevisiae in a mannose-specific manner was determined and subsequently correlated with an L. plantarum WCFS1-based genome-wide genotype database. This led to the identification of four candidate mannose adhesin-encoding genes. Two genes primarily predicted to code for sortase-dependent cell surface proteins displayed a complete gene-trait match. T

SUBMITTER: Pretzer G 

PROVIDER: S-EPMC1196140 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature