Outcomes and Risk Factors for Influenza and Respiratory Syncytial Virus Lower Respiratory Tract Infections and Mortality in Patients With Lymphoma or Multiple Myeloma: A 7-Year Retrospective Cohort Study.

ABSTRACT:

Background

Respiratory viral infection (RVI) is a significant complication in patients with hematologic malignancies. While risk factors of lower respiratory tract infections (LRIs) and mortality have been studied in allogeneic hematopoietic cell transplant recipients, data remain limited for patients with lymphoma and multiple myeloma (MM). We investigated outcomes and risk factors of LRI and mortality secondary to respiratory syncytial virus (RSV) or influenza virus (IFV) infections in these populations.

Methods

We performed a retrospective study in adults with lymphoma or MM with RSV or IFV RVIs between 2016 and 2022. Primary outcomes were LRI and all-cause 30- and 90-day mortality.

Results

We analyzed 440 patients with 490 consecutive viral episodes: 297 (61%) wit

SUBMITTER: Shafat T 

PROVIDER: S-EPMC11961405 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature