Long-term outcomes of pharmacotherapy in patients with persistent postural-perceptual dizziness.

ABSTRACT:

Introduction

Persistent postural-perceptual dizziness (PPPD) is a chronic neuro-otologic disorder characterized by vestibular symptoms such as dizziness, unsteadiness, or non-spinning vertigo. Its pathophysiology is presumed to involve sensory reweighting to visual/somatosensory sensations for maintaining spatial orientation. Serotonergic antidepressants are a major treatment option for PPPD. However, no reports describe the long-term outcomes of these therapeutic agents in patients with PPPD. Therefore, we evaluated the efficacy of antidepressants administered for up to 3 years after initiation in patients with PPPD.

Methods

Forty-three patients with PPPD (12 men and 31 women; median age at the start of treatment: 49 years) who were started on antidepressants at our departm

SUBMITTER: Yagi C 

PROVIDER: S-EPMC11961416 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature