Identifying depression with mixed features: the potential value of eye-tracking features.

ABSTRACT:

Objectives

To investigate the utility of eye-tracking features as a neurobiological marker for identifying depression with mixed features (DMF), a psychiatric disorder characterized by the presence of depressive symptoms alongside subsyndromal manic features, thereby complicating both diagnosis and therapeutic intervention.

Methods

A total of 93 participants were included, comprising 41 patients with major depressive disorder (MDD), of whom 20 were classified as DMF, and 52 healthy controls (HC). Eye-tracking features were collected using an infrared-based device, and participants were evaluated using clinical scales including the Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS), and Brief Psychiatric Rating Scale (BPRS). Performance of extr

SUBMITTER: Liu XC 

PROVIDER: S-EPMC11961420 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature