Comprehensive analysis of the ischemic stroke burden at global, regional, and national levels (1990-2021): trends, influencing factors, and future projections.

ABSTRACT:

Background and purpose

Estimating the global burden of ischemic strokes (IS) is crucial for enhancing prevention and control strategies.

Methods

We collected four epidemiological indicators-prevalence, incidence, deaths, and disability-adjusted life years (DALYs)-for ischemic stroke (IS) from the Global Burden of Disease (GBD) database, which covers the years 1990 to 2021. Our research analyzed the features of the IS burden and described the trends of these four indicators.

Results

The Joinpoint and age-period-cohort models reflected the changing trends in age-standardized indicators. Decomposition analysis examined the factors influencing each epidemiological indicator. The Bayesian Age-Period-Cohort (BAPC) model detailed changes in the number and rate of IS from 199

SUBMITTER: Zhao H 

PROVIDER: S-EPMC11961430 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature