Neurological disability and brain grey matter atrophy in primary progressive multiple sclerosis are determined by microstructural lesional changes, but not by lesion load.

ABSTRACT:

Background

Conventional MRI measures, such as the number and volume of MS lesions, are histologically non-specific and cannot sufficiently explain clinical disability or brain atrophy in MS. Nevertheless, demyelinating plaques exhibit distinct histopathological features in relapsing and progressive multiple sclerosis (MS) subtypes. The aim of this study was to assess microstructural characteristics of MS lesions using quantitative MRI and explore their associations with grey matter (GM) atrophy and clinical disability.

Methods

56 control subjects (CS), 121 patients with relapsing-remitting (RRMS), and 38 patients with primary progressive MS (PPMS) underwent 1.5 T MRI scans and clinical examinations. Lesion and brain segmentation based on T1-weighted and FLAIR images were per

SUBMITTER: Ladopoulos T 

PROVIDER: S-EPMC11961454 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature