Peripheral blood immunoprofiling in patients with polypropylene mesh implants for hernia repair: a single-center cohort study.

ABSTRACT:

Purpose

Surgical mesh, often made from polypropylene, is commonly recommended to enhance hernia repair outcomes in adults. Concerns about polypropylene, as a cause of allergy and/or autoimmune disease prompted this study to evaluate immunological parameters in patients with mesh and healthy controls.

Methodology

A case-control cohort study was conducted at a university hospital. Electronic patient records of hernia repairs using polypropylene mesh (January 2018-April 2022) were analysed. Blood samples from patients and healthy controls were assessed using various methods, including enzyme-linked immunosorbent assay (ELISA), immunofluorescence, immunoblotting, and flow cytometry.

Results

The database search identified 1544 participants. After applying the exclusion cri

SUBMITTER: Jisova B 

PROVIDER: S-EPMC11961455 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature