Impaired remyelination in late-onset multiple sclerosis.

ABSTRACT: A reduced regenerative capacity may contribute to faster disease progression and poorer relapse recovery in multiple sclerosis patients with disease onset after the age of 50, a condition known as late-onset multiple sclerosis (LOMS). We hypothesized that lesions in LOMS patients show more pronounced axonal damage, less remyelination and an altered inflammatory composition, and performed a detailed histopathological analysis of MS biopsies in patients with early-stage LOMS. The number of T cells, B cells, plasma cells, microglia/macrophages, different oligodendrocyte populations as well as the axonal density and acute axonal damage were assessed in 31 LOMS and 30 normal-onset MS (NOMS, 20-40 years old) patients. No major differences in the inflammatory infiltrate or axonal damage were foun

SUBMITTER: Stork L 

PROVIDER: S-EPMC11961469 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature