Minimal change glomerular disease associated with solid neoplasms: a systematic review.

ABSTRACT:

Background

Paraneoplastic minimal change disease (MCD) has been associated with hematological malignancies, whereas solid malignancies are commonly associated with membranous glomerulonephritis. In this systematic review of the literature, we describe the clinical features, treatment and outcome of MCD associated with solid neoplasms.

Methods

We performed a systematic review of the MEDLINE, COCHRANE, EMBASE and SCOPUS databases, including case reports of adult patients with biopsy-proven MCD and solid malignancy, without language or time restrictions.

Results

Sixty-seven papers were included, presenting 86 cases with a mean age of 57.8 ± 14.7 years; 41.0% were women. Nephrotic syndrome was the initial presentation in 96.2% of patients; 67.2% had kidney function impair

SUBMITTER: Cozzo D 

PROVIDER: S-EPMC11961479 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature