Study of epidemiological and molecular characteristics of Brucella strains circulating in Kazakhstan.

ABSTRACT: Brucellosis is one of the most common zoonotic infectious diseases of animals. The causative agent of brucellosis is a highly conserved bacterium of the genus Brucella, which includes 14 species with minor genetic changes. Our work aimed to study the epidemiological and molecular characteristics of Brucella strains circulating in Kazakhstan, including the study of polymorphisms in critical virulence genes using single nucleotide polymorphism (SNP) analysis based on whole genome sequencing (WGS). A total of 21 Brucella isolates obtained in 2023-2024 from cattle, sheep and goats, horses, camels, pigs, dogs, and humans were analyzed. As a result of whole-genome sequencing, 69 virulence genes were detected. The genome of Brucella melitensis, the most virulent species of Brucella, was the most

SUBMITTER: Daugaliyeva A 

PROVIDER: S-EPMC11961523 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature