Associations and mediators between vitiligo and cardiovascular diseases: a Mendelian randomization study.

ABSTRACT: Previous studies yielded conflicting results on the associations between vitiligo and cardiovascular diseases (CVD), and its underlying mechanisms remain unclear. This MR study aims to elucidate the underlying causal association between vitiligo and the risk of CVD, as well as the potential mediator. Using summary statistics from genome-wide association study (GWAS), we conducted a bidirectional two-sample Mendelian randomization (MR) analysis and mediation analysis to investigate the causal association between vitiligo and 13 CVD outcomes and potential mediators. The IVW method was the main MR analysis method, supplemented by MR-Egger, weighted median, and weighted mode methods. Multiple sensitivity analyses were applied to enhance the robustness of the results. Bioinformatics analysis in

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11961564 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature