A LysR-type regulator, CidR, is required for induction of the Staphylococcus aureus cidABC operon.

ABSTRACT: The Staphylococcus aureus cidABC and lrgAB operons have been shown to regulate murein hydrolase activity and affect antibiotic tolerance. The cid operon enhances murein hydrolase activity and antibiotic sensitivity, whereas the lrg operon inhibits these processes. Based on these findings and the structural similarities of the cidA and lrgA gene products to the bacteriophage holin family of proteins, we have proposed that the cid and lrg operons encode holin- and antiholin-like proteins, respectively, that function to control the murein hydrolase activity produced by the bacteria. Analysis of cid operon transcription revealed the presence of two transcripts, one spanning all three cid genes and whose expression is induced by growth in the presence of acetic acid and the other spanning cidB

SUBMITTER: Yang SJ 

PROVIDER: S-EPMC1196168 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature