Associations of the triglyceride-glucose index with mortality mediated by blood urea nitrogen among critically ill patients: a cohort study.

ABSTRACT: Previous studies have shown that an elevated triglyceride-glucose (TyG) index is associated with all-cause mortality in patients. However, the potential mediating effect of blood urea nitrogen (BUN) within these associations has not been reported. The focus of this study was to investigate the potential mediating effect of BUN within these associations. This was a retrospective cohort study of patients in the eICU Collaborative Research Database (eICU-CRD) from 208 different ICUs in the United States between 2014 and 2015 that explored. The primary endpoint of the study was all-cause mortality within 28 days of ICU admission. In addition, the following formula was used to calculate the TyG index: Ln [fasting TG (mg/dL) × FBG (mg/dL)/2]. Cox regression model and subgroup analysis were perfo

SUBMITTER: Liang JH 

PROVIDER: S-EPMC11961709 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature