Autoradiographic comparison between [¹¹C]PiB and [¹⁸F]AZD4694 in human brain tissue.

ABSTRACT:

Background

Amyloid-β imaging through positron emission tomography (PET) has significantly transformed Alzheimer's disease (AD) research. [¹¹C]PiB has been widely used for imaging β-amyloid plaques due to its high affinity and selectivity for amyloid deposits. [¹⁸F]AZD4694 is a more recently developed amyloid-PET imaging agent, which structurally resembles PiB and has less non-specific binding in the white matter than other ¹⁸F-labeled compounds. The purpose of this study is to compare the in vitro binding properties of the amyloid-PET radiotracers [¹¹C]PiB and [¹⁸F]AZD4694 in post-mortem human brain tissue. Total binding was assessed by autoradiography in prefrontal, inferior parietal, posterior cingulate cortices and hippocamp

SUBMITTER: Aliaga A 

PROVIDER: S-EPMC11961831 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature