Synapses mediate the effects of different types of stress on working memory: a brain-inspired spiking neural network study.

ABSTRACT: Acute stress results from sudden short-term events, and individuals need to quickly adjust their physiological and psychological to re-establish balance. Chronic stress, on the other hand, results in long-term physiological and psychological burdens due to the continued existence of stressors, making it difficult for individuals to recover and prone to pathological symptoms. Both types of stress can affect working memory and change cognitive function. In this study, we explored the impact of acute and chronic stress on synaptic modulation using a biologically inspired, data-driven rodent prefrontal neural network model. The model consists of a specific number of excitatory and inhibitory neurons that are connected through AMPA, NMDA, and GABA synapses. The study used a short-term recall to

SUBMITTER: Du C 

PROVIDER: S-EPMC11961926 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature