Generation and characterization of induced pluripotent stem cells of small apes.

ABSTRACT: Small apes (family Hylobatidae), encompassing gibbons and siamangs, occupy a pivotal evolutionary position within the hominoid lineage, bridging the gap between great apes and catarrhine monkeys. Although they possess distinctive genomic and phenotypic features-such as rapid chromosomal rearrangements and adaptations for brachiation-functional genomic studies on small apes have been hindered by the limited availability of biological samples and developmental models. Here, we address this gap by successfully reprogramming primary skin fibroblasts from three small ape species: lar gibbons (Hylobates lar), Abbott's gray gibbons (Hylobates abbotti), and siamangs (Symphalangus syndactylus). Using Sendai virus-based stealth RNA vectors, we generated 31 reprogrammed cell line

SUBMITTER: Hamazaki Y 

PROVIDER: S-EPMC11961953 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature