Antiparasitic activity of Colombian Amazon palm extracts against <i>Giardia lamblia</i> trophozoites: insights into cellular death mechanisms.

ABSTRACT:

Introduction

Colombian plants have a long history of use in traditional medicine and ethnopharmacology, particularly for treating stomach pain, digestive issues, diarrhea, and other gastrointestinal disorders. Recent studies have renewed interest in their potential therapeutic properties.

Methods

This study evaluated the giardicidal activity of 15 crude plant extracts native to the Colombian Amazon against Giardia lamblia (genotype A, strain WB/1267). The MTT colorimetric assay was used to determine the effectiveness of these extracts at a concentration of 500 μg/mL. Extracts showing significant activity were further analyzed to determine their half-maximal inhibitory concentration (IC50). The cell death mechanisms of Attalea butyracea were studied using flow cytometry, conf

SUBMITTER: Garcia-Bustos JJ 

PROVIDER: S-EPMC11961968 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature