Association between hematological inflammatory markers and latent TB infection: insights from NHANES 2011-2012 and transcriptomic data.

ABSTRACT:

Background

Latent tuberculosis infection affects about one-quarter of the global population and can progress to active tuberculosis. Hematological inflammatory markers, such as the systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio, reflect systemic inflammation and immune status but are understudied in latent tuberculosis infection. This study investigates the association between these markers and latent tuberculosis infection in a nationally representative sample.

Methods

Data from 7,042 participants in the 2011-2012 National Health and Nutrition Examination Survey and transcriptomic data from the GSE19491 dataset were analyzed. Latent tuberculosis infection was identified using the QuantiFERON

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11962010 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature